Phosphopantetheine binding
WebSep 5, 2008 · The structure identifies two additional nonenzymatic domains: (i) a pseudo-ketoreductase and (ii) a peripheral pseudo-methyltransferase that is probably a remnant of an ancestral methyltransferase domain maintained in some related polyketide synthases. Web2.8 2.9 Structures of essential biomolecules pantothenate, phosphopantetheine, coenzyme A, and acyl-ACP Biosynthetic pathway of Coenzyme A Sequence similarity of CoA biosynthetic enzymes among several species Selected CoA biosynthetic pathway inhibitors The membranes of gram-negative bacteria Biosynthetic pathway of lipid A
Phosphopantetheine binding
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WebGene Ontology Term: phosphopantetheine binding. GO ID. GO:0031177. Aspect. Molecular Function. Description. Binding to phosphopantetheine, the vitamin pantetheine 4'- … WebStructural and binding studies of phosphopantetheine adenylyl transferase from Acinetobacter baumannii. Phosphopantetheine adenylyltransferase (PPAT, EC. 2.7.7.3) …
WebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins 138 – ‘acyl carrier proteins (ACPs) and peptidyl … WebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins 138 – ‘acyl carrier proteins ... (for 4′-phosphopantetheine 10). The binding of dephospho-CoA was also shown to be competitive with both ATP and phosphopantetheine, whereas pyrophosphate was competitive with ATP ...
WebView publication. Phosphopantetheine-binding site.: (A) Structural superposition of ATP-bound MsFadD32 and adenylate analog- and phosphopantetheine-bound PA1221 protein. The N- and C-terminal ... WebNDA 021160/S-015 Page 2 with PhosLo. Progressive hypercalcemia due to overdose of PhosLo may be severe as to require emergency measures. Chronic hypercalcemia may …
WebOct 5, 2007 · Together with docking simulations that identified a potential phosphopantetheine binding groove, the structural and functional studies reveal that the C9 specificity is a result of active site geometry and substrate ring constraints. The results lay the foundation for the design of novel aromatic polyketide natural products with different ...
WebNov 9, 1999 · The first domain (AL) shows 49% similarity to long-chain fatty acid CoA-ligases and contains a putative ATP binding box. The second and fourth domains (ACP) show 45% similarity to acyl carrier proteins, and both contain a putative 4′-phosphopantetheine binding box. The third domain (KS) is 53% similar to β-ketoacyl synthetases. cybersecurity summer internships near meWebFeb 1, 2024 · The reaction mechanism of PPAT involves a nucleophilic attack by 4′-phosphate of phosphopantetheine on the α-phosphate of ATP in an in-line displacement mechanism, where both the substrates are positioned in a single line. This results in a short lived intermediate pentacovalent transition state. cheap steinway pianosWebPantetheine Phosphate. Phosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins138 – ‘acyl carrier proteins (ACPs) and peptidyl carrier proteins (PCPs), also termed thiolation (T) domains’ – during the biosynthesis of fatty acids (FAs) (use ACPs) (Scheme 23), polyketides (PKs) (use ACPs) … cyber security summer internship programsWebFeb 9, 2024 · Binding poses of the natural substrates 4′-phosphopantetheine (PPSH) and ATP are shown for comparison. C) Hydrogen-bonding interactions and hydrophobic … cyber security summer placementsWebCrystal structures of the PCP-reductase didomain reveal that phosphopantetheine binding alters the orientation of a key Asp, resulting in a productive orientation of the bound nicotinamide. This ensures that further reduction of the aldehyde product does not occur. cheap stephanie urbina jones ticketshttp://nextgen.mgh.harvard.edu/IlluminaChemistry.html cybersecurity summitWebphosphopantetheine prosthetic group in the T domain to yield tyrosyl-S-NovH (Figure 2). It has been our premise that all subsequent modification steps leading to aminocoumarin … cybersecurity summer programs