Phosphatase and actin regulator 1
WebNov 25, 2024 · The PHACTR1 gene belongs to a family of proteins that interact with actin and play a role in the regulation of cell morphology and motility. PHACTR1 is expressed in … WebFeb 22, 2024 · (1) Ezrin is a general cross-linker which binds membrane proteins such as receptors, ion channels, and transporters to the actin cytoskeleton directly or indirectly through scaffold proteins. It also connects the extracellular matrix to the actin cytoskeleton. (2) Ezrin functions as a regulator of G-protein-related proteins.
Phosphatase and actin regulator 1
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WebOct 11, 2024 · Studies have found that the phosphatase actin regulatory factor 1 expression can be related to stroke, but it remains unclear whether changes in phosphatase actin regulatory factor 1 expression also play a role in traumatic brain injury. WebApr 26, 2013 · Furthermore, we identified PHACTR1, an actin-binding protein, to be positively regulated by TGF-β in a miR-584-dependent manner. Moreover, we found TGF-β-mediated down-regulation of miR-584 and increased expression of PHACTR1 to be required for TGF-β-induced cell migration of breast cancer cells.
WebApr 13, 2024 · TRAP5 is a regulator of bone resorption and ... OnTRAP5b without metal ions, which was set as 100%. The phosphatase activity measured with 1–50 mM of different metal ions was considered relative enzyme activity. ... were applied to perform OnTRAP5b expression, and β-actin was amplified using qβ-actin-F and qβ-actin-R as internal control ... WebApr 11, 2024 · Once produced, the Rap phosphatases can immediately exert their regulatory function, either by dephosphorylating or preventing the DNA-binding of their target transcriptional regulator (Figure 1). The pro-peptides encoded by the phr genes follow a more complicated path to become active.
WebJul 23, 2024 · Another group is the phosphatase and actin regulator (Phactr) family [9]; Phactr expression is detected in the brain in a spatiotemporal manner [9, 10]. Phactr family members have been identified as proteins that possess G-actin-binding RPEL motifs and a protein phosphatase 1 (PP1)-binding domain [9]. PP1 comprises a catalytic subunit, which … WebAug 13, 2014 · The PHACTR1 gene encodes the protein phosphatase 1 and actin regulator 1 (PHACTR1), an enzyme regulating endothelial nitricoxide in humans . PHACTR1 has been demonstrated to be an important modulator in the pathophysiology of cardiovascular disease [ 9 ], and it may be involved in the formation of stenosis in cardiac vessels of CAD …
WebThe protein encoded by this gene is a member of the Phosphatase and actin regulator family of proteins. This family member can bind actin and regulate the reorganization of the actin Cytoskeleton. It plays a role in tubule formation and in endothelial cell survival. Polymorphisms in this gene are associated with susceptibility to myocardial infarction, …
WebApr 13, 2024 · IntroductionObscurin (720–870 kDa) is a giant cytoskeletal and signaling protein that possesses both structural and regulatory functions in striated muscles. Immunoglobulin domains 58/59 (Ig58/59) of obscurin bind to a diverse set of proteins that are essential for the proper structure and function of the heart, including giant titin, novex … florian emhoferWebPhosphatase and actin regulator-1 (PHACTR-1) is highly expressed in endothelial cells and neurons (Allen et al., 2004). PHACTR-1 is thought to regulate synaptic plasticity by … florian emmrichWebIntroduction. According to the latest data from the International Diabetes Federation, more than 382 million people are suffering from diabetes in 2013, and by 2035, this number will reach a staggering 592 million, causing 4.6 million deaths each year. 1 Type 2 diabetes mellitus (T2DM) is the most common form and accounts for around 90% of all diabetes … great sunflower project procedureWebOct 11, 2024 · Studies have found that the phosphatase actin regulatory factor 1 expression can be related to stroke, but it remains unclear whether changes in phosphatase actin … floriane petiot theseWebThe human phosphatase and actin regulator 1 (PHACTR1) may be involved in such diseases, but its precise regulatory function remains unclear due to the large number of potential interaction ... great sunsan wine importsWebNov 18, 2014 · The current hypothesis suggests that the phactr–PP1 complex is controlled by the changes in the cytoplasmic G-actin concentration, which regulate the actin cytoskeleton dynamics by modulating the phosphorylation status of … floriane rousselotWebAbstract Background: Some genetic association studies tried to investigate potential associations of phosphatase and actin regulator 1 (PHACTR1) polymorphisms with coronary artery disease (CAD). However, the results of these studies were not consistent. great sunlight spear ds2