WebSep 18, 2024 · Nguyen et al. accurately calculated the folding free energies of several RNA molecules by combining 3D-RISM with coarse-grained molecular dynamics simulations, which establishes a new model for understanding monovalent and divalent influence on nucleic acid folding. WebApr 24, 2024 · This suggested that kinetically formed RNA structures had a dominant effect on gene expression in prokaryotes. The results of this study indicate that it is critical to consider the conformational dynamics of RNA-folding to understand the contributions of the mRNA structures in controlling gene expression.
Programmed −1 ribosomal frameshifting from the perspective of …
WebNov 12, 2014 · Despite the significant progress, modelling of RNA folding dynamics remains a challenging problem. The current form of the theories involves several limitations. First, the theories do not treat folding/unfolding of tertiary folds such as pseudoknots. Second, the theories cannot treat, at the explicitly atomistic level, the effects of cofactors ... WebAug 26, 2024 · This approach has shown good predictive potential. Furthermore, we derived a kinetic ansatz from the fast-folding graph to model the slow part of the folding dynamics. It approximated the usual kinetics framework qualitatively, requiring drastically fewer structures. Our findings suggest that the RNA folding kinetic partitioning mechanism is ... simply coach holidays
Molecular-crowding effects on single-molecule RNA folding ... - PNAS
WebMay 21, 2014 · The impact of crowding by high–molecular-weight polyethylene glycol on the RNA folding thermodynamics is dramatic, with up to ΔΔ G ° ∼ −2.5 kcal/mol changes in free energy and thus >60-fold increase in the folding equilibrium constant ( Keq) for excluded volume fractions of 15%. WebHow does RNA fold? We are now developing a quantitative and predictive framework for RNA folding kinetics and thermodynamics. We have developed a “Reconstitution … WebNov 5, 2024 · To understand how RNA dynamics is regulated and connected to its function, we investigate the folding, conformational dynamics and robustness of Xrn1 resistance … rayscan fairfield heights